Process Analytical Technology: Out of the Lab and into the Line

Process Analytical Technology: Out of the Lab and into the Line

Jim Rydzak
Specere Consulting

Course: SC1267

Intermmediate Level

1 Day Course

Tuesday, March 03, 2020

Analytical Metrology, Green Chemistry, Infrared Spectroscopy, Raman Spectroscopy, Spectroscopy

$875 ($1,225 after 1-9-2020)

More Course Info

Course Description

Process analytical technology (PAT) is a tool for product development, scale up and manufacturing of any chemical product. In this course, you will learn about the benefits of in-process monitoring, how to justify and plan the analysis implementation. Different process analytical tools will be discussed, how to implement them and how to choose between them for your application. How to use PAT to save time and money, improve your green scores, become proficient at PAT, an overview of chemometrics and how various chemometric tools are used along with a section on method development will be discussed. Applications, from various industries will be used to explain concepts and provide examples of implementation.

Target Audience

This course is suited for managers, analytical chemist, engineers and those who want to implement process analytical measurements. It is suited for R&D, Pilot plant and manufacturing chemists and engineers.

Learning Objective


1. Introduction

    • What is Process Analytical Technology?
    • Justification of in-line monitoring
    • Implementing and justification of the PAT Project

2. What is the technology use for PAT?

    • Mid-IR
    • Near IR
    • Raman
    • UV
    • MS
    • Probe technology

3. Chemometrics, overview

    • Principle Component Analysis
    • Statistical Process Control
    • Multivariate Statistical Process Control

4. Method Development

    • Choosing the Technique
    • Parameter selection
    • Purpose of Method
    • Examples of Method development

5. Applications

    • Reaction Chemistry
    • Distillation
    • Dryer Monitoring
    • Blending
    • Granulation
    • Tableting
    • Coating

6. Reference articles and Acknowledgements

Instructor Biography

Jim Rydzak is currently an independent consultant, founder of Specere Consulting. Jim was previously a team manager of the Process Analytical group at GSK and previously at Colgate Palmolive. Jim was a founding member of the ASTM E55 committee which develops standard for Process Analytical Technology (PAT). Jim’s background is in FT-IR, Raman, NIR spectroscopy and chemometrics and has a MS from Ohio University where he worked for Dr. Peter Griffiths. Jim has taught short courses in molecular spectroscopy with for the Center for Professional Advancement. Jim has also taught the short course entitled “Process Analytical Chemistry: Out of the Lab and into the Pipes” on PAT at the FACSS/SciX conference.