Tuesday Nexus: Cannabis
Joshua Crossney, Cannabis Science Conference, CSC Events, LLC
When: 12:30 PM
This presentation will take a close look at several issues in cannabis science- from stigma to standardization. We will also look at progress over the past years- from methods and instrumentation to clinical trials. Lastly, we will examine several emerging topics in cannabis science, from academic programs to contaminants and cannabinomics.
Bob Clifford, Shimadzu Scientific Instruments
When: 1:15 PM
Cannabis has been around for a very long time, dating to its use 10,000 years ago. Today, there are illegal and legal uses throughout the USA and the world. Because of its popularity, there certainly is money to be made. But for those looking to get into the cannabis or hemp industry, there are many considerations. While there are many plant-touching and ancillary businesses in the cannabis and hemp markets, this presentation will mainly focus on the laboratory aspect. There are different considerations for both legacy labs and startup labs. Information provided will include which tests and instruments are required, and what is the return on investment (ROI). In addition to solutions provided by analytical instrument manufacturers, it’s important to become familiar with agencies such as ASTM, AOAC, and USP that also provide methods and solutions. Federal and state regulations are well known, but the independent federal agency of Small Business Administration, Office of Advocacy offers a great resource, serving as a customer voice in finding alternatives to proposed rules that place a cost and time burden on small businesses. This presentation will highlight some of these aspects, providing many with a solid starting point for entering this fast-growing market.
Jeffrey Gast, LECO Corporation
When: 2:00 PM
Moisture determination in plant material is typically done using thermal gravimetric analysis (TGA). The methodology used, specifically the temperature and analytical gas, are important criteria for obtaining an accurate moisture value. Moisture determination in cannabis is complicated due to the various volatile organic compounds (VOC’s); some of which evolve at temperatures typically used for moisture determination. This presentation will outline a multi-technique approach for determining the proper temperature and analytical gas composition to provide the most accurate moisture value in cannabis. Prior to TGA analysis, a representative sample is analyzed on thermally controlled instrumentation that determines moisture directly via Infrared detection in either an oxidizing, or inert atmosphere; thus allowing separation of moisture from VOC’s. This allows the user to determine the temperature and atmosphere necessary to liberate moisture yet minimizing evolution of VOC’s. This information is then used to develop the proper methodology for TGA analysis specific to cannabis.
Katherine Stenerson, MilliporeSigma
When: 2:45 PM
Pesticide and potency are common tests for cannabis laboratories. These assays are not without their headaches. In this session we will present several ideas related to sample preparation and analysis, and then field discussion as to specific needs in the testing arena to optimize and improve potency and pesticide testing of cannabis and cannabis-derived products. In addition, concepts for approaching residual solvent, terpene and mycotoxin analyses will also be presented.
Sean Orlowicz, Phenomenex
When: 3:30 PM
Preparative purification and remediation needs have exploded in the Cannabis and Hemp industry. Various chromatography formats, including Flash, Preparative HPLC purification, Bulk media process purification, SMB, and SFC are among techniques applied in a range of different scenarios. The platform, separation mode, and media phases are also applied variously to each of these as well. When we consider the cost, scale, extraction solvent, purity requirements, cannabinoids of interest and specific chemical contaminants to be eliminated, each scenario can have a unique quality requiring a customized workflow. Here we will review some real-world case studies, eying the practical production needs to guide through the most appropriate pathways to consider in any individual case. Remediation of pesticide contaminated hemp from the contaminated soil to achieve clean CBD for further product formulation using a normal phase flash cartridge clean-up, SFC ultra-purification of cannabinoids using Axia preparative HPLC, and reversed phase Bulk process purification workflows will be among the case studies explored.
Ramkumar Dhandapani, Phenomenex
When: 10:00 AM
Residual solvent analysis has become more and more challenging because of the extensive list of solvents that can be used and the level of these impurities pertaining to specific class. In addition, unknown peak identification and characterization is next to impossible without the help of GC Mass Spec. 624 type phase provides the right balance of retention and selectivity for low and high boiling as well as polar and nonpolar solvents. Having to identify unknown impurities in GCMS on traditional 624 is challenging as it poses active spots as well as high column bleed. In this talk, we will demonstrate ways to overcome challenges in traditional residual solvent analysis, active volatile amine separation and genotoxic N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA) analysis utilizing the benefits of MS compatible, superior deactivated 624 chemistry.
Thibault Brulé, Horiba Scientific
When: 10:45 AM
In this talk, we will unveil latest amazing and patented technology in Raman Ultrafast Imaging from HORIBA Scientific, shortening Raman overnight high definition maps in minutes maps. Applicable to any sample, with no compromise on confocality, available at all laser wavelengths and all spectral resolutions , this new approach will simply revolutionize Raman imaging.
Dr. Eberhardt Kuhn, Shimadzu Scientific Instruments
When: 11:30 AM
Food Contact Materials (FCM) are all materials that come in contact with the food we eat during processing, storage, and consumption. FCM contain a wide range of compounds, such as phthalates, bisphenols, metals, mineral oils, and PFAS. Many of these compounds can have negative effects on human health. This talk will give an overview of the issues and challenges of FCM, and provide updates on the latest regulations and measures to better manage FCM.
Steve Bowen, Fluid Imaging Technology
When: 1:00 PM
Flow Imaging Microscopy or Flow Imaging particle analyzers provide the in-depth characterization of particles in protein therapeutics as recommend by the FDA. Additionally, these particle analyzers can bring increased detail and clarity to the analysis of all subvisible particles in many different industries (ranging from food & beverage, to paint & polymers, to cosmetic, abrasives, printer toner, additive manufacturing and many others). In this talk you’ll learn about the technology behind flow imaging microscopy and understand the advantages it offers over volumetric techniques such as light obscuration, laser diffraction and dynamic light scattering. We’ll discuss advantages and limitations of various methods and provide you with a checklist for how to evaluate different particle characterization methods based on your specific needs and goals. Attendees will receive the e-Book “The Ultimate Guide to Flow Imaging Microscopy”.
Ludivine Fromentoux, Horiba Scientific
When: 1:45 PM
In this talk, we will show how the latest innovation and patented technologies in Raman Ultrafast Imaging from HORIBA Scientific can help to easily analyze complex matrix sample saving time and give high accurate results. This case study will highlight a new approach to managing laboratories challenges, from Pharmaceutic API analysis to polymers sciences.
Phillip Preston, PolyScience
When: 2:30 PM
For almost 60 years PolyScience has been in industry leader when it comes to developing innovative technology for temperature control solutions. While every innovation is a journey into itself, Philip Preston and his team always take the same first step, getting to know customers is what drives their innovation and their commitment to the environment.