High Throughput and High Resolution Mass Spectrometry for Drug Discovery and Clinical Research

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COURSE DESCRIPTION: High-resolution, accurate-mass (HRAM) mass spectrometry techniques have been highly successful in advancing proteomics and metabolomics that revolutionize drug discovery and clinical research. More importantly, HRAM MS has recently evolved from the research into pharmaceutical and clinical routine laboratories. What are the main advantages of HRAM MS? How does it work? How can you apply it to your method development? How to get the most out of your HRAM MS?

In this course, we will introduce an overview of common HRAM MS approaches, and some advanced HRAM data acquisition techniques. We will include practical strategies on how to increase throughput and leverage HRAM for optimized performance, enhanced sensitivity, selectivity, accuracy, and resolution. In addition, good practices and troubleshooting tips will be discussed.

TARGET AUDIENCE: Target audience (Intermediate or advanced)

  • The objective of this short course is for researchers to recognize the advantages of orbitrap-based HRAM technology.
  • Scientists who would like to sharpen their skills of HRAM MS method development and troubleshooting.

    About Dr. Zhou

    Dr. Yu Zhou is a Senior Application Scientist at Thermo Fisher Scientific, USA. She obtained her Ph.D. in Analytical Chemistry from Peking University. She has been engaged in clinical mass spectrometry assay developments and researches, aimed at developing and evaluating new and advanced diagnostic testing procedures. Dr. Zhou has a unique multidisciplinary background in mass spectrometry, chromatography, proteomics, bioinformatics, computer programming, clinical method development, validation, and lab automation.

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