This course will review and apply concepts important for the successful chemical analysis of cannabis plant materials and products. Importantly mass spectrometer (MS) detectors will be discussed in considerable detail including the relative merits of GC/MS and LC/MS including tandem mass spectrometry. These latter techniques are the current ‘gold standard’ for combined sensitivity and selectivity for chemical analysis of complex mixtures. The student will gain an understanding and appreciation of the optimal analytical techniques associated with modern chemical analysis of cannabis and cannabis-related samples from this course.
This course audience includes employees of new cannabis testing laboratories, university undergraduate and graduate students who may see a future in the cannabis analytical industry, and entrepreneurs producing cannabis-derived products. Also, employees of vendors which produce chromatography equipment/supplies and mass spectrometers.
A systematic series of lectures will introduce the basic principles of modern technologies and techniques followed by method development and validation examples. Lectures will introduce and describe HPLC and PDA for potency testing of plant materials, GC/MS and GC/MS/MS for residual solvents and terpenes, LC/MS and LC/MS/MS for determination of pesticides and mycotoxins as well as ICP/MS techniques for the determination of heavy metals in which may be sequestered from the oil by cannabis plants. Current methods for the determination of relevant chemicals in biological samples will also be introduced. The importance of SOP’s, QA/QC and method validation will also be covered.
Professor Jack Henion is Emeritus Professor of Toxicology at Cornell University where he was a member of the College of Veterinary Medicine. Dr. Henion was co-founder of Advion BioSciences in 1993 and is now CSO of Advion, Inc. Professor Henion has received three Doctor Honoris Causa degrees from the University of Ghent, Uppsala University and Albany University. He has published over 235 peer reviewed papers and trained nearly 100 students and post-doctoral scientists. Dr. Henion received the Outstanding Contribution to Anti-Doping Science Award from the Partnership for Clean Competition (PCC) as well as the winner of the 2018 Bioanalysis Outstanding Contribution Award (BOSCA).