Mobile Phase Selection for LC-MS
(Room 232) View Description
Liquid Chromatography mass spectrometry (LC-MS) is a widely used technique in pharamaceuticals, proteomics, metabolomics and biotechnology field. With the advancement of instrument sensitivity, demand for interference free mobile phase is increasing. Selection and optimization of a mobile phase is critical for the overall performance of LC-MS. The quality of LC-MS grade solvents should enable the detection and identification of trace level of compounds. Limited number of mobile phases is compatible with the LC-MS and it is challenging to select the correct mobile phase to achieve the separation of a complex mixture and identification of the separated components by ionization in positive or negative mode depends on choice of additives, optimal ionic strength and pH of the mobile phase.
Particle Size Analysis: Modern Challenges and Solutions
(Room 231) View Description
Particle size significantly impacts the practical performance of many materials. For example it affects blending of fertilizer materials as well as the dose uniformity of active pharmaceutical ingredients (API’s). There are a number of techniques for size analysis, including laser diffraction, dynamic light scattering, image analysis, and sieving. Furthermore, the effect of sampling and dispersion on results is significant and often independent of the choice of analysis technique. In this session we will discuss particle size analysis and related topics such as surface area and shape analysis.
Green Chemistry in Undergraduate Education
(Room 227) View Description
Resources and best practices for teaching green chemistry at the undergraduate level will be discussed. What teaching strategies have been most effective in your classroom? What does green chemistry research look like at the undergraduate level? Come share your successes and challenges in implementing green chemistry at your institution.
Analysis of Excipients in Bioformulations
(Room 226) View Description
Biotherapeutics is a fast growing area in the pharmaceutical industry, where proteins and antibodies are the main class of commercial products and drugs in development. Excipients in biotherapeutics formulation are limited to those approved by GRAS and manufactured pharmaceutical grade. While there is no degradation of hosphate and citrate buffers, histidine is not as stable. Excipients, like sucrose and trehalose could contain potentially harmful reducing sugars. Non-ionic surfactants, routinely used in biotherapeutics formulations are well known to contain peroxides, oxidative reagents. The suggested topic: stability of excipients, stability indicating assays, analysis of the degradation products of the excipients. Methods used? Raw material suppliers? Container closures effects?
Standards, Interoperability and Open Data
(Room 225) View Description
As the demand for open data increases in both public and private sectors, interoperable standards will gain in importance. Multiple standardization initiatives are active in the lab informatics space. Building a standard is a multi-year effort, so communication and collaboration between end users and standards groups is crucial to foster adoption and use. Like our previous Networking Sessions, we bring together the stakeholders in this area. Working together, we leverage synergies and make a larger impact on the scientific community. We invite groups interested in standardization and interoperability of instrument data both from an end user and vendor perspective. Topics for discussion include community requirements, status of current standardization efforts and real-world applications.