LC-MS-MS Analysis of Emerging Contaminants (EDCs, PPCPs and PFCs) and Nanomaterials in the Environment
The course material should be of interest to environmental chemists, either doing a PhD or not, involved in method development, analytical chemists, laboratory personnel,and governmental and industry regulators. Participants should have some general knowledge of mass MS. It can be considered a course between intermediate and advanced level.
In this course you will learn about the various Liquid chromatography- tandem mass spectrometric (LC-MS-MS) methods used for the determination of endocrine disrupting compounds (EDCs) ,pharmaceuticals and personal care products (PPCPs), perfluorinated compounds (PFCs) and carbon-based nanomaterials in environmental samples. Compounds listed will be: steroid sex hormones, Pharmaceuticals such as antibiotics, ß-blockers, anti-inflammatory drugs, lipid regulators, cyutostaics ,psychiatric drugs and illicit drugs, UV filter used as Personal Care Products as well as Perfluorinated compounds (PFCs) such as perfluoro- alkylcarboxylic acids, – sulfonates and -sulfonamides are listed too. Fullerenes were selected as target nanomaterials. LC-MS-MS has gained in popularity, due to the sensitivity, ruggedness and ease of use given by API interfaces, such as electrospray (ESI) and atmospheric pressure chemical ionization (APCI),atmospheric pressure photoinization interface (APPI) respectively combined with a new generation of MS equipment (QqQ, linear on-trap Q TRAP and time of flight Q TOF and Orbitrap Velos and Q Exactive). LC-MS-MS have become often routine methods for the 200 Emerging chemicals listed in this short course. Comparison of hybrid instruments like LC-Q-TOF-MS , Q-Orbitrap-Exactive and Q Trap LC-tandem MS for multi-residue analysis of emerging contaminants will also be reported.